The DNA Builder
Folate
Folate / L-Methylfolate (5-MTHF)
Key Benefits
DNA Synthesis
Required for nucleotide synthesis and cell division, critical during pregnancy and growth.
Mood & Cognition
Supports neurotransmitter production and reduces depression risk, especially with MTHFR mutations.
Cardiovascular Health
Lowers homocysteine levels, reducing cardiovascular disease risk.
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Activation Synergies
required
Vitamin B12
B12 and folate work together in methylation. Supplementing one without the other can mask B12 deficiency.
Recommended Dosage
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400-800
mcg / daily
L-Methylfolate (5-MTHF) is active form, especially important for those with MTHFR gene mutations (~40% of population). Folic acid requires conversion.
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Deficiency Indicators
- Anemia (macrocytic)
- Fatigue and weakness
- Depression or cognitive issues
- Neural tube defects (pregnancy)
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Scientific Citations
NIH Office of Dietary Supplements
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Folate Fact Sheet
Status: In Your Stack Status: Not in Stack